Circadian expression of FGF21 is induced by PPARα activation in the mouse liver

Oishi, Katsutaka; Uchida, Daisuke; Ishida, Norio

doi:10.1016/j.febslet.2008.09.046

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Volume 582, Issue 25 , Pages 3639-3642, 29 October 2008

Circadian expression of FGF21 is induced by PPARα activation in the mouse liver

Edited by Laszlo Nagy

Katsutaka Oishi
- Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
- Corresponding authors. Fax: +81 29 861 9499.
Daisuke Uchida
- Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8502, Japan
Norio Ishida
- Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8502, Japan
- Corresponding authors. Fax: +81 29 861 9499.

Received 25 August 2008; received in revised form 19 September 2008; accepted 23 September 2008. published online 06 October 2008.

Abstract

Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates the expression of genes associated with lipid metabolism. Recent studies have suggested that the expression of PPARα-dependent fibroblast growth factor 21 (FGF21) plays important roles in adaptation to fasting, such as lipolysis and ketogenesis. We found that a nighttime injection of bezafibrate, a ligand of PPARα, effectively induced FGF21 expression, whereas a daytime injection did not affect it. Furthermore, bezafibrate-induced circadian FGF21 expression was abolished in PPARα-deficient mice. These observations suggest that bezafibrate-induced circadian FGF21 expression is due to circadian variations in the responsiveness of the PPARα system in the liver.

Keywords: Circadian rhythm, FGF21, Fibrate, PDK4, Fasting, PPARα