FEBS Letters
Volume 582, Issue 25 , Pages 3663-3668, 29 October 2008

MicroRNA-183 regulates Ezrin expression in lung cancer cells

Edited by Lukas Huber

  • Guofu Wang

      Affiliations

    • The 2nd Affiliated Hospital, School of Medicine, College of Life Sciences, Zhejiang University, No. 88, Jiefang Road, Hangzhou, China
    • Zhejiang Hospital, Hangzhou, China
    • ,
  • Weimin Mao

      Affiliations

    • Zhejiang Hospital, Hangzhou, China
    • ,
  • Shu Zheng

      Affiliations

    • The 2nd Affiliated Hospital, School of Medicine, College of Life Sciences, Zhejiang University, No. 88, Jiefang Road, Hangzhou, China
    • Corresponding Author InformationCorresponding author.

Received 9 July 2008; received in revised form 11 September 2008; accepted 25 September 2008. published online 06 October 2008.

Abstract 

Lung cancer is the leading cause of cancer death. However, the mechanism of lung cancer relapse and metastasis has been poorly elucidated. Recent researches have addressed the role of MicroRNAs (miRNAs) in mediating tumor metastasis. In the present study, we identified microRNA-183 (miR-183) as a potential metastasis-inhibitor. Expression level of miR-183 was reversely correlated with the metastatic potential of lung cancer cells. Furthermore, over-expression of miR-183 inhibited migration and invasion of lung cancer cells. Mechanistically, we identified VIL2-coding-protein Ezrin as a bona fide target of miR-183. We also found that miR-183 could regulate the expression of other genes involved in migration and invasion. Taken together, our findings demonstrated a new role and regulatory mechanism of miR-183 in controlling cancer metastasis.

Keywords: MicroRNA-183, Ezrin, VIL2 gene, Metastasis, Lung neoplasm

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PII: S0014-5793(08)00798-9

doi:10.1016/j.febslet.2008.09.051

FEBS Letters
Volume 582, Issue 25 , Pages 3663-3668, 29 October 2008

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