FEBS Letters
Volume 582, Issue 27 , Pages 3719-3722, 12 November 2008

Energetics of kinesin-1 stepping mechanism

Edited by Aleksander Benjak

Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan

Received 23 August 2008; received in revised form 12 October 2008; accepted 14 October 2008. published online 22 October 2008.

Abstract 

Kinesin-1 is a dimeric motor protein that transports cellular cargo along microtubules by using the energy released from ATP hydrolysis and moving processively in 8-nm steps. Recent novel studies at the single molecular level have provided extensive knowledge on how kinesin-1 converts the free energy of ATP hydrolysis and uses it for “walking” along microtubules. In this review, I have discussed the important topics pertaining to the energetics of kinesin-1 stepping mechanism and the consensus walking model.

Keywords: Kinesin-1, Microtubule, Energetics, Brownian ratchet, Lever arm, Walking model

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PII: S0014-5793(08)00837-5

doi:10.1016/j.febslet.2008.10.019

FEBS Letters
Volume 582, Issue 27 , Pages 3719-3722, 12 November 2008

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