FEBS Letters
Volume 582, Issue 30 , Pages 4137-4142, 24 December 2008

Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia–reperfusion in mice

Edited by Aleksander Benjak

Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, 1101 E. Marshall St. Sanger Hall, Box 980281, Richmond, VA 23298-0281, USA

Received 9 September 2008; received in revised form 20 October 2008; accepted 11 November 2008. published online 26 November 2008.

Abstract 

We investigated the role of microRNAs (miRNA) in protection against ischemia/reperfusion (I/R) injury in heart. Mice subjected to cytoprotective heat-shock (HS) showed a significant increase of miRNA-1, miRNA-21 and miRNA-24 in the heart. miRNAs isolated from HS mice and injected into non-HS mice significantly reduced infarct size after I/R injury, which was associated with the inhibition of pro-apoptotic genes and increase in anti-apoptotic genes. Chemically synthesized miRNA-21 also reduced infarct size, whereas a miRNA-21 inhibitor abolished this effect. Overall, these studies for the first time provide evidence for the potential role of endogenously synthesized miRNA’s in cardioprotection following I/R injury.

Keywords: Microrna, Heat-shock, Myocardial infarction, Apoptosis

 

PII: S0014-5793(08)00922-8

doi:10.1016/j.febslet.2008.11.014

FEBS Letters
Volume 582, Issue 30 , Pages 4137-4142, 24 December 2008

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