FEBS Letters
Volume 582, Issue 30 , Pages 4113-4116, 24 December 2008

Beyond HPV: Oncomirs as new players in cervical cancer

Edited by Varda Rotter

Translational Cancer Research Laboratory, Rajiv Gandhi Center for Biotechnology, Thycaud P.O., Thiruvananthapuram 695 014, Kerala, India

Received 17 October 2008; accepted 13 November 2008. published online 24 November 2008.

Abstract 

MicroRNAs (miRNAs) are a recently discovered family of 18–24 nucleotide non-coding RNAs that can negatively regulate target mRNAs. All studied multicellular eukaryotes utilize miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. This review discusses the various cancer-relevant miRNAs (oncomirs) especially in cervical tumorigenesis and the potential role of oncomirs as therapeutic agents and targets for the treatment of cervical cancer.

Abbreviations: miRNAs, microRNAs, HPV, human papillomavirus, og, oncogenic, tsg, tumor suppressor gene, EBV, Epstein-Barr virus, KSHV, Kaposi sarcoma-associated herpesvirus, HSV, Herpes Simplex virus, SV40, Simian virus 40

Keywords: MicroRNA, Oncomirs, Cervical cancer, Apoptosis, Tumor suppressor

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(08)00925-3

doi:10.1016/j.febslet.2008.11.011

FEBS Letters
Volume 582, Issue 30 , Pages 4113-4116, 24 December 2008

Article Tools