FEBS Letters
Volume 583, Issue 2 , Pages 259-265, 22 January 2009

IL-1 family in breast cancer: Potential interplay with leptin and other adipocytokines

Edited by Masayuki Miyasaka

  • Stéphane Perrier

      Affiliations

    • Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 1382496363.
    • ,
  • Florence Caldefie-Chézet

      Affiliations

    • Université Clermont 1, UFR Pharmacie, EA4233, CRNH-Auvergne, Clara, France
    • ,
  • Marie-Paule Vasson

      Affiliations

    • Université Clermont 1, UFR Pharmacie, EA4233, CRNH-Auvergne, Clara, France
    • Unité de Nutrition, Centre Jean Perrin, 63001 Clermont-Ferrand Cedex 1, France

Received 8 September 2008; received in revised form 17 November 2008; accepted 11 December 2008. published online 25 December 2008.

Abstract 

Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.

Abbreviations: IL-1, interleukin-1, IL-1ra, interleukin-1 receptor antagonist, HMEC, human mammary epithelial cells, ObR, leptin receptor, BMI, body mass index

Keywords: IL-1, Leptin, Adipocytokine, Breast cancer, Obesity

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PII: S0014-5793(08)01021-1

doi:10.1016/j.febslet.2008.12.030

FEBS Letters
Volume 583, Issue 2 , Pages 259-265, 22 January 2009

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