FEBS Letters
Volume 583, Issue 3 , Pages 531-541, 4 February 2009

Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury

Edited by Lukas Huber

  • Tiziano M. Scarabelli

      Affiliations

    • Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University School of Medicine, 22201 Moross Road, Detroit, USA
    • These four authors contributed equally to this work.
    • ,
  • Sofia Mariotto

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • These four authors contributed equally to this work.
    • Corresponding Author InformationCorresponding author.
    • ,
  • Safwat Abdel-Azeim

      Affiliations

    • Laboratoire de Modélisation et Ingéniérie des Protéines, Université Paris-Sud, Bât 430, 91405 Orsay, France
    • These four authors contributed equally to this work.
    • ,
  • Kazuo Shoji

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • These four authors contributed equally to this work.
    • ,
  • Elena Darra

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • ,
  • Anastasis Stephanou

      Affiliations

    • Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    • ,
  • Carol Chen-Scarabelli

      Affiliations

    • Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University School of Medicine, 22201 Moross Road, Detroit, USA
    • ,
  • Jean Didier Marechal

      Affiliations

    • Laboratoire de Modélisation et Ingéniérie des Protéines, Université Paris-Sud, Bât 430, 91405 Orsay, France
    • Unitat de Química Física, Departament de Química, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    • ,
  • Richard Knight

      Affiliations

    • Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    • ,
  • Anna Ciampa

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • ,
  • Louis Saravolatz

      Affiliations

    • Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University School of Medicine, 22201 Moross Road, Detroit, USA
    • ,
  • Alessandra Carcereri de Prati

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • ,
  • Zhaokan Yuan

      Affiliations

    • Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University School of Medicine, 22201 Moross Road, Detroit, USA
    • ,
  • Elisabetta Cavalieri

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • ,
  • Marta Menegazzi

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy
    • ,
  • David Latchman

      Affiliations

    • Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    • ,
  • Cosimo Pizza

      Affiliations

    • Dipartimento di Scienze Farmaceutiche, Università di Salerno, via Ponte Don Melillo 84084 Fisciano, Salerno, Italy
    • ,
  • David Perahia

      Affiliations

    • Laboratoire de Modélisation et Ingéniérie des Protéines, Université Paris-Sud, Bât 430, 91405 Orsay, France
    • ,
  • Hisanori Suzuki

      Affiliations

    • Sezione di Chimica Biologica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Strada Le Grazie, 8, I-37134 Verona, Italy

Received 19 November 2008; received in revised form 18 December 2008; accepted 18 December 2008. published online 29 December 2008.

Abstract 

Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.

Keywords: Antioxidant flavonoid, Heart ischemia/reperfusion, STAT1, Apoptosis, Surface plasmon resonance

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PII: S0014-5793(08)01029-6

doi:10.1016/j.febslet.2008.12.037

FEBS Letters
Volume 583, Issue 3 , Pages 531-541, 4 February 2009

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