FEBS Letters
Volume 583, Issue 4 , Pages 597-606, 18 February 2009

Sphingolipids and membrane environments for caveolin

Edited by Felix Wieland

Center of Excellence on Neurodegenerative Diseases, Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, 20090 Segrate, Milano, Italy

Received 31 October 2008; received in revised form 7 January 2009; accepted 8 January 2009. published online 21 January 2009.

Abstract 

Caveolin-1, and probably also -2 and -3, can organize multimolecular membrane complexes involved in transmembrane traffic, cell adhesion and signal transduction. In this review, we discuss on the importance of caveolin membrane environment in regulating the architecture and function of such complexes, with a special emphasis on the role of sphingolipids.

Abbreviations: EGFR, epidermal growth factor receptor, GPI, glycosylphosphatidylinositol, IR, insulin receptor, PAG, phosphoprotein associated with glycosphingolipids, PDGFR, platelet-derived growth factor receptor, RTK, receptor tyrosine kinases

Keywords: Caveolae, Caveolin-1, Sphingolipids, Gangliosides, Lipid rafts

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PII: S0014-5793(09)00035-0

doi:10.1016/j.febslet.2009.01.007

FEBS Letters
Volume 583, Issue 4 , Pages 597-606, 18 February 2009

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