FEBS Letters
Volume 583, Issue 4 , Pages 680-684, 18 February 2009

Regulation of the activity and expression of ERK8 by DNA damage

Edited by Angel Nebreda

  • Iva V. Klevernic

      Affiliations

    • MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH Scotland, UK
    • ,
  • Niall M.B. Martin

      Affiliations

    • Kudos Pharmaceuticals Ltd., Cambridge Science Park, Cambridge CB4 OWG, UK
    • ,
  • Philip Cohen

      Affiliations

    • MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Sir James Black Centre, Dundee, DD1 5EH Scotland, UK
    • Corresponding Author InformationCorresponding author. Fax: +44 1382 223778.

Received 1 October 2008; received in revised form 12 January 2009; accepted 12 January 2009. published online 21 January 2009.

Abstract 

We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism.

Keywords: ERK8, MAPK, DNA damage, MMS

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PII: S0014-5793(09)00038-6

doi:10.1016/j.febslet.2009.01.011

FEBS Letters
Volume 583, Issue 4 , Pages 680-684, 18 February 2009

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