FEBS Letters
Volume 583, Issue 4 , Pages 627-632, 18 February 2009

Kaiso is a bimodal modulator for Wnt/β-catenin signaling

Edited by Lukas Huber

BRB 723, Department of Genetics, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, United States

Received 11 August 2008; received in revised form 12 January 2009; accepted 12 January 2009. published online 21 January 2009.

Abstract 

The Wnt family of secreted ligands plays critical roles during embryonic development and tumorigenesis. Here we show that Kaiso, a dual specific DNA-binding protein, functions as a bimodal regulator of canonical Wnt signaling. Loss-of-function analysis of Kaiso abrogated Wnt-mediated reporter activity and axis duplication, whereas gain-of-function analysis of Kaiso dose-dependently resulted in synergistic and suppressive effects. Our analyses further suggest Kaiso can regulate TCF/LEF1-activity for these effects via modulating HDAC1 and β-catenin-complex formation. Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an ApcMin/+ background.

Stuctured summary

MINT-6823807: HDAC1 (uniprotkb:Q13547) physically interacts (MI:0218) with beta catenin (uniprotkb:P35222) by anti tag coimmunoprecipitation (MI:0007)

MINT-6823820: axin (uniprotkb:O15169) physically interacts (MI:0218) with beta catenin (uniprotkb:P35222) by anti tag coimmunoprecipitation (MI:0007)

Keywords: Wnt, Kaiso, Xenopus

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PII: S0014-5793(09)00039-8

doi:10.1016/j.febslet.2009.01.012

FEBS Letters
Volume 583, Issue 4 , Pages 627-632, 18 February 2009

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