FEBS Letters
Volume 583, Issue 5 , Pages 903-908, 4 March 2009

ATM blocks tunicamycin-induced endoplasmic reticulum stress

Edited by Robert Barouki

  • Long He

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Sun Ok Kim

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Osong Kwon

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Sook Jung Jeong

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Min Soo Kim

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Hee Gu Lee

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • ,
  • Hiroyuki Osada

      Affiliations

    • Antibiotics Laboratory, Chemical Biology Department, Advanced Science Institute, RIKEN 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
    • ,
  • Mira Jung

      Affiliations

    • Department of Radiation Medicine, Georgetown University School of Medicine, Washington, DC 20057-1482, USA
    • ,
  • Jong Seog Ahn

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Fax: +82 42 860 4595.
    • ,
  • Bo Yeon Kim

      Affiliations

    • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, P.O. Box 115, Daejeon 305-806, Republic of Korea
    • Corresponding Author InformationCorresponding authors. Fax: +82 42 860 4595.

Received 9 January 2009; received in revised form 28 January 2009; accepted 1 February 2009. published online 09 February 2009.

Abstract 

Endoplasmic reticulum stress (ER-stress) is associated with ataxia telangiectasia mutated (ATM) gene. We present here conclusive data showing that ATM blocks ER-stress induced by tunicamycin or ionizing radiation (IR). X-box protein-1 (XBP-1) splicing, GRP78 expression and caspase-12 activation were increased by tunicamycin or IR in Atm-deficient AT5BIVA fibroblasts. Activation of caspase-12 and caspase-3 by tunicamycin was significantly reduced in cells transfected with wild-type Atm (AT5BIVA/wtATM). Atm knockdown by siRNA, however, noticeably elevated ER-stress and chemosensitivity to tunicamycin. In summary, we present substantial data demonstrating that ATM blocks the ER stress signaling associated with cancer cell proliferation.

Keywords: Ataxia telangiectasia mutated, ER stress, Tunicamycin, X-box protein-1

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PII: S0014-5793(09)00094-5

doi:10.1016/j.febslet.2009.02.002

FEBS Letters
Volume 583, Issue 5 , Pages 903-908, 4 March 2009

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