Robustness and topology of the yeast cell cycle Boolean network

Abstract 

Yeast cell cycle Boolean network was used as a case study of robustness to protein noise. Robustness was interpreted as involving stability of G1 steady state and sequence of gene expression from cell cycle START to stationary G1. A robustness measure to evaluate robustness strength of a network was proposed. Robust putative networks corresponding to the same steady state and sequence of gene expression of wild-type network were sampled. Architecture of wild-type yeast cell cycle network can be revealed by average topology profile of sampled robust putative networks.

Abbreviations: YCC, yeast cell cycle, SIT, signal input trajectory, MFPL, maximal flux pipe line

Keywords: Yeast cell cycle network, Robustness, Network topology, Boolean network