FEBS Letters
Volume 583, Issue 8 , Pages 1327-1330, 17 April 2009

Ca2+-modulated ONE-GC odorant signal transduction

Edited by Ned Mantei

  • Teresa Duda

      Affiliations

    • Corresponding Author InformationCorresponding authors. Fax: +1 215 780 3125 (R.K. Sharma).
    • ,
  • Rameshwar K. Sharma

      Affiliations

    • Corresponding Author InformationCorresponding authors. Fax: +1 215 780 3125 (R.K. Sharma).

Research Divisions of Biochemistry and Molecular Biology, The Unit of Regulatory and Molecular Biology, Salus University, Elkins Park, PA 19027, United States

Received 11 February 2009; received in revised form 14 March 2009; accepted 17 March 2009. published online 23 March 2009.

Abstract 

In a subset of olfactory epithelium the odorant receptor guanylate cyclase, ONE-GC, is a central transduction component of the cyclic GMP signaling pathway. The odorant binds to the extracellular domain and activates its intracellular catalytic domain to generate the odorant second messenger, cyclic GMP. The present study demonstrates that it is a two-step, Ca2+-independent and Ca2+-dependent, sequential process. In step one, the odorant, uroguanylin, binds ONE-GC and primes it for stimulation. In step two, Ca2+-bound neurocalcin δ binds to the defined intracellular domain and saturates ONE-GC activity. A prototype model is proposed that depicts this signal transduction process.

Keywords: Cyclic GMP, ONE-GC membrane guanylate cyclase, Odorant signal transduction

 

PII: S0014-5793(09)00222-1

doi:10.1016/j.febslet.2009.03.036

FEBS Letters
Volume 583, Issue 8 , Pages 1327-1330, 17 April 2009

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