| | Serum amyloid A and protein AA: Molecular mechanisms of a transmissible amyloidosisEdited by Peter Brzezinski To the memory of D. Carleton Gajdusek (1923–2008). Received 19 March 2009; received in revised form 15 April 2009; accepted 16 April 2009. published online 23 April 2009. Abstract Systemic AA-amyloidosis is a complication of chronic inflammatory diseases and the fibril protein AA derives from the acute phase reactant serum AA. AA-amyloidosis can be induced in mice by an inflammatory challenge. The lag phase before amyloid develops can be dramatically shortened by administration of a small amount of amyloid fibrils. Systemic AA-amyloidosis is transmissible in mice and may be so in humans. Since transmission can cross species barriers it is possible that AA-amyloidosis can be induced by amyloid in food, e.g. foie gras. In mice, development of AA-amyloidosis can also be accelerated by other components with amyloid-like properties. A new possible risk factor may appear with synthetically made fibrils from short peptides, constructed for tissue repair. a Division of Cell Biology, Diabetes Research Centre, Department of Clinical and Experimental Medicine, Linköping University, 58185 Linköping, Sweden b Department of Medical Cell Biology, Uppsala University, 75123 Uppsala, Sweden c Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-75185 Uppsala, Sweden  Corresponding author. Fax: +46 18 552739.
PII: S0014-5793(09)00310-X doi:10.1016/j.febslet.2009.04.026 © 2009 Federation of European Biochemical Societies | |
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ABSTRACT
