Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells

Tóth, Balázs I.; Benkő, Szilvia; Szöllősi, Attila G.; Kovács, László; Rajnavölgyi, Éva; Bíró, Tamás

doi:10.1016/j.febslet.2009.04.031

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Volume 583, Issue 10 , Pages 1619-1624, 19 May 2009

Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells

Edited by Bing Sun

Balázs I. Tóth
- Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary
- BIT and SzB contributed equally to this work.
Szilvia Benkő
- Department of Immunology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Hungary
- BIT and SzB contributed equally to this work.
Attila G. Szöllősi
- Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary
László Kovács
- Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary
Éva Rajnavölgyi
- Department of Immunology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Hungary
Tamás Bíró
- Department of Physiology, University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine, 4032 Debrecen, Nagyerdei krt. 98, P.O. Box 22, Hungary
- Corresponding author. Fax: +36 52 432 289.

Received 8 January 2009; received in revised form 31 March 2009; accepted 20 April 2009. published online 27 April 2009.

Abstract

The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions.

Keywords: Transient receptor potential vanilloid-1, Human dendritic cell, Differentiation, Cytokine release, Anti-inflammatory