Mapping of sex hormone receptors and their modulators along the nephron of male and female mice

Grimont, Adrien; Bloch-Faure, May; Abida, Boutaïna El; Crambert, Gilles

doi:10.1016/j.febslet.2009.04.032

« Previous Next »FEBS Letters
Volume 583, Issue 10 , Pages 1644-1648, 19 May 2009

Mapping of sex hormone receptors and their modulators along the nephron of male and female mice

Edited by Robert Barouki

UPMC Univ. Paris 6/CNRS/INSERM, Centre de Recherche des Cordeliers, Laboratoire de Génomique, Physiologie et Physiopathologie, Rénales, UMRS, 872 Equipe 3 ERL 7226, 15 rue de l’Ecole de Medecine, F-75006 Paris Cedex, France

Received 3 February 2009; received in revised form 16 April 2009; accepted 20 April 2009. published online 27 April 2009.

Abstract

Renal functions are regulated by steroid sex hormones, but the exhaustive identification of their receptors along the nephron is still lacking. Here, we have localized all known nuclear or membrane-bound sex hormone receptors and some of their activators along the nephron of male and female mice. Almost all receptors are present in male and female kidney, some of them having very restricted localization. Only one gene tested among 11 (ARA54) exhibits a gender difference in the level of its expression. This first “renal map” of sex steroid receptor expression may serve as a pre-requisite for investigating the role of these hormones on kidney functions.

Keywords: Kidney, Steroid receptor, Estrogen, Progesterone, Testosterone, Gender difference