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Volume 583, Issue 12, Pages 1817-1824 (18 June 2009)


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IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis

Edited by Lukas Huber

Colin D. White, Matthew D. Brown, David B. SacksCorresponding Author Informationemail address

Received 27 March 2009; received in revised form 28 April 2009; accepted 2 May 2009. published online 11 May 2009.

Abstract 

The IQGAP family comprises three proteins in humans. The best characterized is IQGAP1, which participates in protein–protein interactions and integrates diverse signaling pathways. IQGAP2 and IQGAP3 harbor all the domains identified in IQGAP1, but their biological roles are poorly defined. Proteins that bind IQGAP1 include Cdc42 and Rac1, E-cadherin, β-catenin, calmodulin and components of the mitogen-activated protein kinase pathway, all of which are involved in cancer. Here, we summarize the biological functions of IQGAPs that may contribute to neoplasia. Additionally, we review published data which implicate IQGAPs in cancer and tumorigenesis. The cumulative evidence suggests IQGAP1 is an oncogene while IQGAP2 may be a tumor suppressor.

Brigham and Women’s Hospital and Harvard Medical School, Thorn 530, 75 Francis Street, Boston, MA 02115, USA

Corresponding Author InformationCorresponding author. Fax: +1 617 278 6921.

PII: S0014-5793(09)00373-1

doi:10.1016/j.febslet.2009.05.007


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