| | Bridging the gap: From protein misfolding to protein misfolding diseasesEdited by Per Hammarström Received 28 May 2009; accepted 9 June 2009. published online 22 June 2009. Abstract Protein misfolding and aggregation are pathognomic for a number of the most common age-related degenerative diseases. Great progress has been made in studying protein aggregation in the test tube and also in replicating protein aggregation in vertebrate animal models of these diseases. However, we argue here that the development and effective integration of emerging techniques such as the methods of nanoscience and the use of invertebrate models are now providing powerful new opportunities to advance our current understanding of the fundamental origins of these disorders. Abbreviations: SDS–PAGE, sodium dodecyl sulfate–polyacrylamide gel electrophoresis, AD, Alzheimer’s Disease, Aβ, Amyloid Beta, APP, Amyloid Precursor Protein, AFM, Atomic Force Microscopy, TCCD, Two Colour Coincidence Detection, QCM, Quartz Crystal Microbalance, SEC, Size Exclusion Chromatography, FRAP, Fluorescence Recovery After Photobleaching, sHsp, small Heat shock protein Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK  Corresponding author.
PII: S0014-5793(09)00464-5 doi:10.1016/j.febslet.2009.06.030 © 2009 Federation of European Biochemical Societies. Published by Elsevier BV. All rights reserved. | |
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ABSTRACT
