FEBS Letters
Volume 583, Issue 17 , Pages 2701-2709, 3 September 2009

The COPI system: Molecular mechanisms and function

Edited by Lukas Huber

  • R. Beck

      Affiliations

    • Yale University School of Medicine, Department of Cell Biology, 333 Cedar Street, SHM C-232, New Haven, CT 06520, USA
    • These authors contributed equally.
    • ,
  • M. Ravet

      Affiliations

    • Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
    • These authors contributed equally.
    • ,
  • F.T. Wieland

      Affiliations

    • Biochemistry Center, Heidelberg University, Im Neuenheimer Feld 328, D-69120 Heidelberg, Germany
    • Corresponding Author InformationCorresponding authors.
    • ,
  • D. Cassel

      Affiliations

    • Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel
    • Corresponding Author InformationCorresponding authors.

Received 16 June 2009; received in revised form 7 July 2009; accepted 13 July 2009. published online 22 July 2009.

Abstract 

Transport of membranes and proteins in eukaryotic cells is mediated by vesicular carriers. Here we review the biogenesis and functions of COPI vesicles, carriers that operate in the early secretory pathway. We focus on mechanisms mediating coat recruitment, uptake of cargo, vesicle budding and fission, and finally dissociation of the coat. In this context, recent findings on the interplay between machinery and auxiliary proteins in COPI vesicle formation and function will be discussed. Specifically, we will weigh the pros and cons of recent data on roles of the small GTP binding protein Arf1, of Arf1GAPs, and lipids during COPI carrier formation.

Keywords: COPI, Golgi, Vesicular transport, Arf, Coatomer

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PII: S0014-5793(09)00550-X

doi:10.1016/j.febslet.2009.07.032

Refers to corrigendum:

  • Corrigendum to “The COPI system: Molecular mechanisms and function” [FEBS Lett. 583 (2009) 2701–2709] , 20 October 2009

    R. Beck, M. Rawet, F.T. Wieland, D. Cassel
    FEBS Letters 3 November 2009 (Vol. 583, Issue 21, Page 3541)

FEBS Letters
Volume 583, Issue 17 , Pages 2701-2709, 3 September 2009

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