FEBS Letters
Volume 584, Issue 9 , Pages 1694-1699, 3 May 2010

Membrane glycolipids in stem cells

Edited by Sandro Sonnino

Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA

Received 3 August 2009; received in revised form 22 August 2009; accepted 24 August 2009. published online 27 August 2009.

Abstract 

Stem cells, such as embryonic stem cells, hematopoietic stem cells, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells, are undifferentiated cells that are endowed with a high potential for proliferation and the capacity for self-renewal with retention of pluri/multipotency to differentiate into their progenies. Recently, studies regarding the biological functions of glycolipids and cell surface microdomains (caveolae, lipid rafts, or glycolipid-enriched microdomains) in stem cells are emerging. In this review, we introduce the expression patterns of glycolipids and the functional roles of cell surface microdomains in stem cells.

Keywords: Glycolipid, Cell surface microdomain, Embryonic stem cell, Hematopoietic stem cell, Neural stem cell, Mesenchymal stem cell, Cancer stem cell

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PII: S0014-5793(09)00656-5

doi:10.1016/j.febslet.2009.08.026

FEBS Letters
Volume 584, Issue 9 , Pages 1694-1699, 3 May 2010

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