FEBS Letters
Volume 583, Issue 21 , Pages 3377-3387, 3 November 2009

Deceptively simple but simply deceptive – Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects

Edited by Vladimir Skulachev

  • Jan Gruber

      Affiliations

    • Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • ,
  • Li Fang Ng

      Affiliations

    • Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • ,
  • Suresh Kumar Poovathingal

      Affiliations

    • Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore
    • ,
  • Barry Halliwell

      Affiliations

    • Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    • Corresponding Author InformationCorresponding author. Address: National University of Singapore, University Hall, Lee Kong Chian Wing, UHL #05-02G, 21 Lower Kent Ridge Road, Singapore 119077, Singapore. Fax: +65 6775 2207.

Received 3 July 2009; received in revised form 1 September 2009; accepted 29 September 2009. published online 05 October 2009.

Abstract 

The nematode worm Caenorhabditis elegans (C. elegans) is increasingly popular as a model organism for aging studies as well as for testing antioxidants and other compounds for effects on longevity. However, results in the literature are sometimes confusing and contradictory . This review introduces C. elegans as a model organism, discusses aspects that make it attractive for aging and antioxidant research, and addresses some problems and potential artifacts.

Keywords: Aging, Reactive oxygen species, Antioxidant, Lifespan, Artifact, Caenorhabditis elegans

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PII: S0014-5793(09)00755-8

doi:10.1016/j.febslet.2009.09.051

FEBS Letters
Volume 583, Issue 21 , Pages 3377-3387, 3 November 2009

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