Positive-feedback loops in cell cycle progression

Abstract 

A positive-feedback loop is a simple motif that is ubiquitous to the modules and networks that comprise cellular signaling systems. Signaling behaviors that are synonymous with positive feedback include amplification and rapid switching, maintenance, and the coherence of outputs. Recent advances have been made towards understanding how positive-feedback loops function, as well as their mechanistic basis in controlling eukaryotic cell cycle progression. Some of these advances will be reviewed here, including: how cyclin controls passage through Start and maintains coherence of G1/S regulon expression in yeast; how Polo-like kinase 1 activation is driven by Bora and Aurora A, and its expression is stimulated by Forkhead Box M1 in mammalian cells; and how some of the various dynamic behaviors of spindle assembly and anaphase onset can be produced.

Abbreviations: CDK1, cyclin-dependent kinase 1, APC, anaphase-promoting complex, Plk1, Polo-like kinase 1, FoxM1, Forkhead Box M1, Emi1, early mitotic inhibitor 1, NuMA, nuclear mitotic apparatus, END, Emi1/NuMA/dynein–dynactin

Keywords: Positive feedback, Cell cycle, Spindle assembly, Anaphase-promoting complex, Switching, Coherence