FEBS Letters
Volume 583, Issue 24 , Pages 3905-3913, 17 December 2009

Systems biology of lipid metabolism: From yeast to human

Edited by Johan Elf

Department of Chemical and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE 412 96 Gothenburg, Sweden

Received 25 August 2009; received in revised form 13 October 2009; accepted 20 October 2009. published online 23 October 2009.

Abstract 

Lipid metabolism is highly relevant as it plays a central role in a number of human diseases. Due to the highly interactive structure of lipid metabolism and its regulation, it is necessary to apply a holistic approach, and systems biology is therefore well suited for integrated analysis of lipid metabolism. In this paper it is demonstrated that the yeast Saccharomyces cerevisiae serves as an excellent model organism for studying the regulation of lipid metabolism in eukaryotes as most of the regulatory structures in this part of the metabolism are conserved between yeast and mammals. Hereby yeast systems biology can assist to improve our understanding of how lipid metabolism is regulated.

Keywords: Systems biology, Lipid metabolism, Yeast, Metabolic model

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PII: S0014-5793(09)00842-4

doi:10.1016/j.febslet.2009.10.054

FEBS Letters
Volume 583, Issue 24 , Pages 3905-3913, 17 December 2009

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