FEBS Letters
Volume 584, Issue 2 , Pages 303-309, 21 January 2010

Transfer RNA processing in archaea: Unusual pathways and enzymes

Edited by Michael Ibba

  • Ilka U. Heinemann

      Affiliations

    • Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA
    • Fax: +1 203 432 6202.
    • ,
  • Dieter Söll

      Affiliations

    • Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA
    • Department of Chemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA
    • Fax: +1 203 432 6202.
    • ,
  • Lennart Randau

      Affiliations

    • Department of Molecular Biophysics and Biochemistry, Yale University, P.O. Box 208114, 266 Whitney Avenue, New Haven, CT 06520-8114, USA
    • Corresponding Author InformationCorresponding author. Fax: +1 203 432 6202.

Received 1 October 2009; received in revised form 21 October 2009; accepted 22 October 2009. published online 28 October 2009.

Abstract 

Transfer RNA (tRNA) molecules are highly conserved in length, sequence and structure in order to be functional in the ribosome. However, mostly in archaea, the short genes encoding tRNAs can be found disrupted, fragmented, with permutations or with non-functional mutations of conserved nucleotides. Here, we give an overview of recently discovered tRNA maturation pathways that require intricate processing steps to finally generate the standard tRNA from these unusual tRNA genes.

Keywords: tRNA processing, Trans-splicing, tRNA introns, Splicing endonuclease, C-to-U editing

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PII: S0014-5793(09)00859-X

doi:10.1016/j.febslet.2009.10.067

FEBS Letters
Volume 584, Issue 2 , Pages 303-309, 21 January 2010

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