Multiple routes of protein transport from endosomes to the trans Golgi network

Pfeffer, Suzanne R.

doi:10.1016/j.febslet.2009.10.075

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Volume 583, Issue 23 , Pages 3811-3816, 3 December 2009

Multiple routes of protein transport from endosomes to the trans Golgi network

Edited by Antonella De Matteis

Department of Biochemistry, 279 Campus Drive B400, Stanford University School of Medicine, Stanford, CA 94305-5307, USA

Received 28 August 2009; received in revised form 27 October 2009; accepted 27 October 2009. published online 29 October 2009.

Abstract

Proteins use multiple routes for transport from endosomes to the Golgi complex. Shiga and cholera toxins and TGN38/46 are routed from early and recycling endosomes, while mannose 6-phosphate receptors are routed from late endosomes. The identification of distinct molecular requirements for each of these pathways makes it clear that mammalian cells have evolved more complex targeting mechanisms and routes than previously anticipated.

Abbreviations: MPR, mannose 6-phosphate receptor, TGN, trans Golgi network

Keywords: Endosome, Golgi, Rab GTPase, Mannose 6-phosphate receptor, Shiga and cholera toxin