FEBS Letters
Volume 584, Issue 9 , Pages 1670-1677, 3 May 2010

Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins

Edited by Wilhelm Just

  • Morihisa Fujita

      Affiliations

    • Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan
    • ,
  • Taroh Kinoshita

      Affiliations

    • Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
    • WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
    • Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan
    • Corresponding Author InformationCorresponding author. Address: Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan. Fax: +81 6 6879 5233.

Received 7 September 2009; received in revised form 27 October 2009; accepted 27 October 2009. published online 02 November 2009.

Abstract 

Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational modification in eukaryotes. In mammalian cells, approximately 150 proteins on the plasma membrane are attached to the cell surface by GPI anchors, which confer specific properties on proteins, such as association with membrane microdomains. The structures of lipid and glycan moieties on GPI anchors are remodeled during biosynthesis and after attachment to proteins. The remodeling processes are critical for transport and microdomain-association of GPI-anchored proteins. Here, we describe the structural remodeling of GPI anchors and genes required for the processes in mammals, yeast, and trypanosomes.

Keywords: Glycosylphosphatidylinositol, Remodeling, Microdomain, Lipid raft, Endoplasmic reticulum, Golgi

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PII: S0014-5793(09)00871-0

doi:10.1016/j.febslet.2009.10.079

FEBS Letters
Volume 584, Issue 9 , Pages 1670-1677, 3 May 2010

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