FEBS Letters
Volume 584, Issue 1 , Pages 15-21, 4 January 2010

c-Abl and Src-family kinases cross-talk in regulation of myeloid cell migration

Edited by Giulio Superti-Furga

  • Anna Baruzzi

      Affiliations

    • Department of Pathology, University of Verona, Italy
    • ,
  • Ilaria Iacobucci

      Affiliations

    • Institute of Hematology and Oncology “L. e A. Seragnoli”, University of Bologna, Italy
    • ,
  • Simona Soverini

      Affiliations

    • Institute of Hematology and Oncology “L. e A. Seragnoli”, University of Bologna, Italy
    • ,
  • Clifford A. Lowell

      Affiliations

    • Department of Laboratory Medicine, University of California, San Francisco, CA 94143, United States
    • ,
  • Giovanni Martinelli

      Affiliations

    • Institute of Hematology and Oncology “L. e A. Seragnoli”, University of Bologna, Italy
    • ,
  • Giorgio Berton

      Affiliations

    • Department of Pathology, University of Verona, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Pathology, University of Verona, Strada le Grazie 8, 37134 Verona, Italy. Fax: +39 045 8027127.

Received 10 September 2009; received in revised form 28 October 2009; accepted 4 November 2009. published online 09 November 2009.

Abstract 

Cytoskeleton dynamics are regulated by Src-family tyrosine kinases (SFKs) and c-Abl. We found that the SFK members Hck and c-Fgr regulate tyrosine phosphorylation of c-Abl and c-Abl associates with β1 integrin-bound Hck or c-Fgr in murine macrophages. Studies with selective inhibitors and cells from SFK-deficient mice showed that c-Abl and SFK regulate migration and activation of the small GTPases Cdc42 and Rac in macrophages. Additionally, human neutrophil chemotactic activity was reduced by c-Abl inhibitors, and neutrophils from chronic myeloid leukaemia patients displayed an increased chemotactic ability. Hence, Src-family kinase and c-Abl cross-talk in the regulation of myeloid cell migration.

Structured summary

MINT-7296608: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Hck (uniprotkb:P08103), Abl (uniprotkb:P00520) and Fgr (uniprotkb:P14234) by anti bait coimmunoprecipitation (MI:0006) MINT-7296596: Integrin beta-1 (uniprotkb:P09055) physically interacts (MI:0914) with Fgr (uniprotkb:P14234) and Abl (uniprotkb:P00520) by anti bait coimmunoprecipitation (MI:0006)

Keywords: Macrophage, Neutrophil, Tyrosine kinase, Chemotaxis, Signal transduction

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PII: S0014-5793(09)00901-6

doi:10.1016/j.febslet.2009.11.009

FEBS Letters
Volume 584, Issue 1 , Pages 15-21, 4 January 2010

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