FEBS Letters
Volume 583, Issue 24 , Pages 3959-3965, 17 December 2009

Fungal regulatory evolution: cis and trans in the balance

Edited by Stefan Hohmann

  • Dawn Anne Thompson

      Affiliations

    • Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 01242, United States
    • ,
  • Aviv Regev

      Affiliations

    • Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 01242, United States
    • Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 01240, United States
    • Corresponding Author InformationCorresponding author. Address: Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 01242, United States.

Received 15 October 2009; received in revised form 9 November 2009; accepted 10 November 2009. published online 13 November 2009.

Abstract 

Regulatory divergence is likely a major driving force in evolution. Comparative genomics is being increasingly used to infer the evolution of gene regulation. Ascomycota fungi are uniquely suited among eukaryotes for regulatory evolution studies, due to broad phylogenetic scope, many sequenced genomes, and tractability of genomic analysis. Here we review recent advances in the identification of the contribution of cis- and trans-factors to expression divergence. Whereas current strategies have led to the discovery of surprising signatures and mechanisms, we still understand very little about the adaptive role of regulatory evolution. Empirical studies including experimental evolution, comparative functional genomics and hybrid and engineered strains are showing early promise toward deciphering the contribution of regulatory divergence to adaptation.

Abbreviations: TF, transcription factor, RP, ribosomal proteins, WGD, whole genome duplication

Keywords: Fungal, Regulatory, Evolution, Expression, Divergence

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PII: S0014-5793(09)00936-3

doi:10.1016/j.febslet.2009.11.032

FEBS Letters
Volume 583, Issue 24 , Pages 3959-3965, 17 December 2009

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