| | Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathwayEdited by Lukas Huber Received 20 October 2009; received in revised form 3 December 2009; accepted 12 December 2009. published online 17 December 2009. Abstract A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-κB pathway. The combination of curcumin and IFNα exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents. a Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea b Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo 113-8519, Japan  Corresponding author. Fax: +82 51 513 9258.
PII: S0014-5793(09)01065-5 doi:10.1016/j.febslet.2009.12.019 © 2009 Federation of European Biochemical Societies | |
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ABSTRACT
