FEBS Letters
Volume 584, Issue 7 , Pages 1327-1334, 2 April 2010

Autophagy in the fission yeast Schizosaccharomyces pombe

Edited by Noboru Mizushima

  • Hiroyuki Mukaiyama

      Affiliations

    • Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka 812-8581, Japan
    • ,
  • Mai Nakase

      Affiliations

    • Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka 812-8581, Japan
    • ,
  • Taro Nakamura

      Affiliations

    • Department of Biology, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585, Japan
    • ,
  • Yoshimi Kakinuma

      Affiliations

    • Laboratory of Molecular Physiology and Genetics, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan
    • ,
  • Kaoru Takegawa

      Affiliations

    • Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6-10-1, Fukuoka 812-8581, Japan
    • Corresponding Author InformationCorresponding author. Fax: +81 92 642 2849.

Received 30 November 2009; received in revised form 18 December 2009; accepted 18 December 2009. published online 25 December 2009.

Abstract 

Autophagy is a non-selective degradation process in eukaryotic cells. The genome sequence of the fission yeast Schizosaccharomyces pombe has revealed that many of the genes required for autophagy are common between the fission yeast and budding yeast, suggesting that the basic machinery of autophagy is conserved between these species. Autophagy in fission yeast is specifically induced by nitrogen starvation based on monitoring a GFP–Atg8p marker. Upon nitrogen starvation, fission yeast cells exit the vegetative cell cycle and initiate sexual differentiation to produce spores. Most of the nitrogen used for de novo protein synthesis during sporulation derives from the autophagic protein degradation system. This review focuses on the recent advances in the role of autophagy in fission yeast.

Keywords: Autophagy, Starvation, Meiosis, Sporulation, Fission yeast

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PII: S0014-5793(09)01083-7

doi:10.1016/j.febslet.2009.12.037

FEBS Letters
Volume 584, Issue 7 , Pages 1327-1334, 2 April 2010

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