Autophagy takes flight in Drosophila

Abstract 

Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes.

Abbreviations: Atg1, autophagy-related gene 1, TOR, target of rapamycin, PI3K, phosphoinositide 3-kinase, Ulk1, Unc-51 like kinase 1, S6K, RPS6-p70-protein kinase, JNK, Jun-N-terminal kinase

Keywords: Autophagy-related gene 1, Unc-51 like kinase 1, Vps34, Jun-N-terminal kinase, Target of rapamycin