FEBS Letters
Volume 584, Issue 7 , Pages 1302-1312, 2 April 2010

Regulation of autophagy by phosphatidylinositol 3-phosphate

Edited by Noboru Mizushima

Signalling Programme, Babraham Institute, Cambridge CB22 3AT, UK

Received 4 December 2009; received in revised form 7 January 2010; accepted 8 January 2010. published online 13 January 2010.

Abstract 

The simple phosphoinositide phosphatidylinositol 3-phosphate (PI(3)P) has been known to have important functions in endocytic and phagocytic traffic, and to be required for the autophagic pathway. In all of these settings, PI(3)P appears to create platforms that serve to recruit specific effectors for membrane trafficking events. In autophagy, PI(3)P may form the platform for autophagosome biogenesis.

Keywords: Autophagy, Phosphoinositide, Signalling, Endoplasmic reticulum, PI 3-Kinase

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PII: S0014-5793(10)00029-3

doi:10.1016/j.febslet.2010.01.011

FEBS Letters
Volume 584, Issue 7 , Pages 1302-1312, 2 April 2010

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