Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

Ryu, Shin-Young; Beutner, Gisela; Dirksen, Robert T.; Kinnally, Kathleen W.; Sheu, Shey-Shing

doi:10.1016/j.febslet.2010.01.032

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Volume 584, Issue 10 , Pages 1948-1955, 17 May 2010

Mitochondrial ryanodine receptors and other mitochondrial Ca²⁺ permeable channels

Edited by Adam Szewczyk

Shin-Young Ryu
- Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, United States
- Department of Basic Sciences, New York University College of Dentistry, New York, NY 10010, United States
Gisela Beutner
- Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, United States
Robert T. Dirksen
- Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, United States
Kathleen W. Kinnally
- Department of Basic Sciences, New York University College of Dentistry, New York, NY 10010, United States
Shey-Shing Sheu
- Department of Pharmacology and Physiology, and Mitochondrial Research Innovation Group, University of Rochester Medical Center, Rochester, NY 14642, United States
- Corresponding author. Address: University of Rochester Medical Center, 601 Elmwood Ave, Box 711, Rochester, NY 14642, United States. Fax: +1 (585) 273 2652.

Received 29 November 2009; received in revised form 11 January 2010; accepted 18 January 2010. published online 21 January 2010.

Abstract

Ca²⁺ channels that underlie mitochondrial Ca²⁺ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca²⁺ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca²⁺ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca²⁺ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca²⁺ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca²⁺ channels.

Keywords: Ca²⁺ channel, Mitochondrial Ca²⁺ uniporter (MCU), Mitochondrial ryanodine receptor (mRyR), Rapid mode Ca²⁺ uptake (RaM), Ruthenium red, Ru360, Ryanodine