FEBS Letters
Volume 584, Issue 9 , Pages 1659-1664, 3 May 2010

The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation

Edited by Wilhelm Just

  • Denis Corbeil

      Affiliations

    • Tissue Engineering Laboratories, BIOTEC, Technische Universität Dresden, Tatzberg 47–49, 01307 Dresden, Germany
    • ,
  • Anne-Marie Marzesco

      Affiliations

    • Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    • ,
  • Michaela Wilsch-Bräuninger

      Affiliations

    • Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    • ,
  • Wieland B. Huttner

      Affiliations

    • Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    • Corresponding Author InformationCorresponding author. Fax: +49 (0) 351 210 1600.

Received 25 January 2010; accepted 25 January 2010. published online 01 February 2010.

Abstract 

Prominin-1 (CD133) is a cholesterol-interacting pentaspan membrane protein concentrated in plasma membrane protrusions. In epithelial cells, notably neuroepithelial stem cells, prominin-1 is found in microvilli, the primary cilium and the midbody. These three types of apical membrane protrusions are subject to remodeling during (neuro)epithelial cell differentiation. The protrusion-specific localization of prominin involves its association with a distinct cholesterol-based membrane microdomain. Moreover, the three prominin-1-containing plasma membrane protrusions are the origin of at least two major subpopulations of prominin-1-containing extracellular membrane particles. Intriguingly, the release of these particles has been implicated in (neuro)epithelial cell differentiation.

Keywords: Cholesterol, Membrane polarity, Microvilli, Primary cilium, Prominin-1

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(10)00083-9

doi:10.1016/j.febslet.2010.01.050

FEBS Letters
Volume 584, Issue 9 , Pages 1659-1664, 3 May 2010

Article Tools

* Image Usage & Resolution