FEBS Letters
Volume 584, Issue 7 , Pages 1280-1286, 2 April 2010

Current knowledge of the pre-autophagosomal structure (PAS)

Edited by Noboru Mizushima

Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology, 4259-S2-12 Nagatsuta-cho, Midori-ku, Yokohama 226-8503, Japan

Received 28 December 2009; received in revised form 1 February 2010; accepted 1 February 2010. published online 05 February 2010.

Abstract 

Autophagy is a system for degradation of bulk cellular components in lytic compartments, vacuoles, or lysosomes when eukaryotic cells face with nutrient starvation. In this review, we focus on the pre-autophagosomal structure (PAS), a functional entity responsible for autophagosome formation in Saccharomyces cerevisiae, and discuss its relevance to autophagy in mammalian cells.

Keywords: Autophagy, Autophagosome, Pre-autophagosomal structure, Protein degradation, Atg proteins

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PII: S0014-5793(10)00093-1

doi:10.1016/j.febslet.2010.02.001

FEBS Letters
Volume 584, Issue 7 , Pages 1280-1286, 2 April 2010

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