FEBS Letters
Volume 584, Issue 7 , Pages 1335-1341, 2 April 2010

Role of autophagy in Caenorhabditis elegans

Edited by Noboru Mizushima

  • Attila Lajos Kovacs

      Affiliations

    • Cell Physiology Laboratory, Department of Anatomy, Cell and Developmental Biology, Eötvös Loránd University, Budapest, Hungary
    • ,
  • Hong Zhang

      Affiliations

    • National Institute of Biological Sciences, Beijing, PR China
    • Corresponding Author InformationCorresponding author. Address: National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, PR China. Fax: +86 10 80727517.

Received 7 January 2010; received in revised form 31 January 2010; accepted 1 February 2010. published online 05 February 2010.

Abstract 

Autophagy is an evolutionarily conserved intracellular catabolic system. During Caenorhabditis elegans development, autophagy plays an important role in many physiological processes, including survival under starvation conditions, modulation of life span, and regulation of necrotic cell death caused by toxic ion-channel variants. Recently, it has been demonstrated that during embryogenesis, basal levels of autophagy selectively remove a group of proteins in somatic cells, including the aggregate-prone components of germline P granules. Degradation of these protein aggregates provides a genetic model to identify essential autophagy components and also to elucidate how the autophagic machinery selectively recognizes and degrades specific targets during animal development.

Keywords: Autophagy, PGL granule, Caenorhabditis elegans

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PII: S0014-5793(10)00095-5

doi:10.1016/j.febslet.2010.02.002

FEBS Letters
Volume 584, Issue 7 , Pages 1335-1341, 2 April 2010

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