FEBS Letters
Volume 584, Issue 10 , Pages 1966-1974, 17 May 2010

TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADP

  • Michael X. Zhu

      Affiliations

    • Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, Columbus, OH, USA
    • Corresponding Author InformationCorresponding author. Fax: +1 614 292 5379.
    • ,
  • Jianjie Ma

      Affiliations

    • Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA
    • ,
  • John Parrington

      Affiliations

    • Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    • ,
  • Antony Galione

      Affiliations

    • Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, UK
    • ,
  • A. Mark Evans

      Affiliations

    • Centre for Integrative Physiology, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, Scotland, UK

Received 6 January 2010; received in revised form 10 February 2010; accepted 11 February 2010. published online 15 February 2010.

Edited by Adam Szewczyk

Abstract 

Two-pore channels (TPCs or TPCNs) are novel members of the large superfamily of voltage-gated cation channels with slightly higher sequence homology to the pore-forming subunits of voltage-gated Ca2+ and Na+ channels than most other members. Recent studies demonstrate that TPCs locate to endosomes and lysosomes and form Ca2+ release channels that respond to activation by the Ca2+ mobilizing messenger, nicotinic acid adenine dinucleotide phosphate (NAADP). With multiple endolysosomal targeted NAADP receptors now identified, important new insights into the regulation of endolysosomal function in health and disease will therefore be unveiled.

Keywords: Acidic organelle, Calcium signaling, Calcium channel, IP3 receptor, Ryanodine receptor, Bafilomycin

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PII: S0014-5793(10)00132-8

doi:10.1016/j.febslet.2010.02.028

FEBS Letters
Volume 584, Issue 10 , Pages 1966-1974, 17 May 2010

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