FEBS Letters
Volume 584, Issue 7 , Pages 1313-1318, 2 April 2010

The role of PI3P phosphatases in the regulation of autophagy

Edited by Noboru Mizushima

  • Isabelle Vergne

      Affiliations

    • Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    • Corresponding Author InformationCorresponding author. Address: Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. Fax: +1 (505) 272 6029.
    • ,
  • Vojo Deretic

      Affiliations

    • Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    • Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA

Received 31 December 2009; received in revised form 15 February 2010; accepted 16 February 2010. published online 24 February 2010.

Abstract 

Autophagy initiation is strictly dependent on phosphatidylinositol 3-phosphate (PI3P) synthesis. PI3P production is under tight control of PI3Kinase, hVps34, in complex with Beclin-1. Mammalian cells express several PI3P phosphatases that belong to the myotubularin family. Even though some of them have been linked to serious human diseases, their cellular function is largely unknown. Two recent studies indicate that PI3P metabolism involved in autophagy initiation is further regulated by the PI3P phosphatases Jumpy and MTMR3. Additional pools of PI3P, upstream of mTOR and on the endocytic pathway, may modulate autophagy indirectly, suggesting that other PI3P phosphatases might be involved in this process. This review sums up our knowledge on PI3P phosphatases and discusses the recent progress on their role in autophagy.

Keywords: Autophagy, Myotubularin, PI3P, Phosphatase, Jumpy, MTMR14

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PII: S0014-5793(10)00158-4

doi:10.1016/j.febslet.2010.02.054

FEBS Letters
Volume 584, Issue 7 , Pages 1313-1318, 2 April 2010

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