FEBS Letters
Volume 584, Issue 11 , Pages 2176-2182, 3 June 2010

Lipid droplets: A dynamic organelle moves into focus

Edited by Wilhelm Just

Max-Planck-Institut für biophysikalische Chemie, Abteilung für molekulare Entwicklungsbiologie, Am Fassberg 11, 37077 Göttingen, Germany

Received 16 February 2010; received in revised form 15 March 2010; accepted 16 March 2010. published online 19 March 2010.

Abstract 

Lipid droplets (LDs) were perceived as static storage deposits, which passively participate in the energy homeostasis of both cells and entire organisms. However, this view has changed recently after the realization of a complex and highly dynamic LD proteome. The proteome contains key components of the fat mobilization system and proteins that suggest LD interactions with a variety of cell organelles, including the endoplasmic reticulum, mitochondria and peroxisomes. The study of LD cell biology, including cross-talk with other organelles, the trafficking of LDs in the cell and regulatory events involving the LD coat proteins is now on the verge of leaving its infancy and unfolds that LDs are highly dynamic cellular organelles.

Keywords: Lipid droplet, Organelle interaction, Endoplasmic reticulum, Vesicles

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(10)00234-6

doi:10.1016/j.febslet.2010.03.022

FEBS Letters
Volume 584, Issue 11 , Pages 2176-2182, 3 June 2010

Article Tools

* Image Usage & Resolution