FEBS Letters
Volume 584, Issue 11 , Pages 2168-2175, 3 June 2010

Lipid droplets lighting up: Insights from live microscopy

Edited by Wilhelm Just

Molecular Cell Biology Laboratory Internal Medicine IV, Im Neuenheimer Feld 345, University of Heidelberg, D-69120 Heidelberg, Germany

Received 1 March 2010; received in revised form 19 March 2010; accepted 22 March 2010. published online 29 March 2010.

Abstract 

Lipid droplets emerge as important intracellular organelles relevant for lipid homeostasis and the pathophysiology of metabolic diseases. Here, we present a personal view on the current knowledge about the biogenesis of mammalian cytoplasmic lipid droplets, with a focus on microscopy and especially live imaging. We also discuss difficulties related to the lipid droplet proteome, contentious views on lipid droplet growth, and last but not least the evidence for the heterogeneity of lipid droplets within a single cell. We conclude with an outline of the most important future challenges.

Keywords: Lipid droplet, Live microscopy, Biogenesis, Targeting

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PII: S0014-5793(10)00247-4

doi:10.1016/j.febslet.2010.03.035

FEBS Letters
Volume 584, Issue 11 , Pages 2168-2175, 3 June 2010

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