NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix

Dent, Myrna A.R.; Segura-Anaya, Edith; Alva-Medina, Janeth; Aranda-Anzaldo, Armando

doi:10.1016/j.febslet.2010.04.073

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Volume 584, Issue 13 , Pages 2767-2771, 2 July 2010

NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix

Edited by Gianni Cesareni

Myrna A.R. Dent
- Laboratorio de Neurociencias, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
Edith Segura-Anaya
- Laboratorio de Neurociencias, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
- Laboratorio de Biología Molecular, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
Janeth Alva-Medina
- Laboratorio de Neurociencias, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
- Laboratorio de Biología Molecular, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
Armando Aranda-Anzaldo
- Laboratorio de Biología Molecular, Facultad de Medicina, Universidad Autónoma del Estado de México, Apartado Postal 428, C.P. 50000, Toluca, Edo. Méx., Mexico
- Corresponding author. Fax: +52 722 2174142.

Received 23 February 2010; received in revised form 31 March 2010; accepted 28 April 2010. published online 07 May 2010.

Abstract

NeuN is an antigen detected in the nucleus of neurons in a wide range of vertebrates and so it is widely used as a tool for detecting neuronal cells. NeuN has been recently identified as Fox-3, a new member of the Fox-1 gene family of splicing factors. The predominant localization of NeuN/Fox-3 to neuronal nuclei and its role in splicing pose the question of the nuclear compartmentalization of such a protein. Here we provide evidence that NeuN/Fox-3 is an intrinsic component of the neuronal nuclear matrix and a reliable marker of nuclear speckles in neurons.