Metabolism of postsynaptic recombination intermediates

Adelman, Carrie A.; Boulton, Simon J.

doi:10.1016/j.febslet.2010.05.023

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Volume 584, Issue 17 , Pages 3709-3716, 10 September 2010

Metabolism of postsynaptic recombination intermediates

Edited by Wilhelm Just

DNA Damage Response Laboratory, Cancer Research UK, London Research Institute, Clare Hall, Blanche Lane, South Mimms EN6 3LD, UK

Received 16 April 2010; accepted 14 May 2010. published online 20 May 2010.

Abstract

DNA double strand breaks and blocked or collapsed DNA replication forks are potentially genotoxic lesions that can result in deletions, aneuploidy or cell death. Homologous recombination (HR) is an essential process employed during repair of these forms of damage. HR allows for accurate restoration of the damaged DNA through use of a homologous template for repair. Although inroads have been made towards understanding the mechanisms of HR, ambiguity still surrounds aspects of the process. Until recently, relatively little was known concerning metabolism of postsynaptic RAD51 filaments or how synthesis dependent strand annealing intermediates are processed. This review discusses recent findings implicating RTEL1, HELQ and the Caenorhabditis elegans RAD51 paralog RFS-1 in post-strand exchange events during HR.

Keywords: Homologous recombination, RTEL1, HELQ, RAD51 paralog, Postsynaptic, RAD51 filament, SDSA