FEBS Letters
Volume 584, Issue 17 , Pages 3696-3702, 10 September 2010

Regulation of homologous recombination at telomeres in budding yeast

Edited by Wilhelm Just

Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark

Received in revised form 14 May 2010; accepted 17 May 2010. published online 24 May 2010.

Abstract 

Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.

Keywords: Homologous recombination (HR), Recombinational telomere elongation (RTE), Replicative senescence, Rad52, Replication protein A, Cdc13

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PII: S0014-5793(10)00430-8

doi:10.1016/j.febslet.2010.05.037

FEBS Letters
Volume 584, Issue 17 , Pages 3696-3702, 10 September 2010

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