FEBS Letters
Volume 584, Issue 17 , Pages 3773-3778, 10 September 2010

Defending the end zone: Studying the players involved in protecting chromosome ends

Edited by Wilhelm Just

  • Suzanne S. Chan

      Affiliations

    • Department of Genetics, The M.D. Anderson Cancer Center, 1010 Holcombe Blvd., Houston, TX 77030, USA
    • ,
  • Sandy Chang

      Affiliations

    • Department of Genetics, The M.D. Anderson Cancer Center, 1010 Holcombe Blvd., Houston, TX 77030, USA
    • Department of Hematopathology, The M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Present address: Yale University School of Medicine, 333 Cedar St., New Haven, CT 06520, USA.

Received 1 June 2010; received in revised form 14 June 2010; accepted 14 June 2010. published online 18 June 2010.

Abstract 

The linear nature of eukaryotic chromosomes leaves natural DNA ends susceptible to triggering DNA damage responses. Telomeres are specialized nucleoprotein structures that comprise the “end zone” of chromosomes. Besides having specialized sequences and structures, there are six resident proteins at telomeres that play prominent roles in protecting chromosome ends. In this review, we discuss this team of proteins, termed shelterin, and how it is involved in regulating DNA damage signaling, repair and replication at telomeres.

Keywords: Telomere, Shelterin, DNA damage response, NHEJ

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PII: S0014-5793(10)00506-5

doi:10.1016/j.febslet.2010.06.016

FEBS Letters
Volume 584, Issue 17 , Pages 3773-3778, 10 September 2010

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