FEBS Letters
Volume 584, Issue 15 , Pages 3250-3259, 4 August 2010

Brown vs white adipocytes: The PPARγ coregulator story

Edited by Wilhelm Just

  • Arjen Koppen

      Affiliations

    • Department of Metabolic and Endocrine Diseases, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    • Netherlands Metabolomics Centre, The Netherlands
    • ,
  • Eric Kalkhoven

      Affiliations

    • Department of Metabolic and Endocrine Diseases, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    • Netherlands Metabolomics Centre, The Netherlands
    • Department of Paediatric Immunology, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
    • Corresponding Author InformationCorresponding author at: Department of Metabolic and Endocrine Diseases, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands.

Received 14 May 2010; received in revised form 21 June 2010; accepted 22 June 2010. published online 29 June 2010.

Abstract 

The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors. The peroxisome proliferator-activated receptor γ (PPARγ) is considered to be one of the master regulators of adipocyte differentiation. The presence of two functionally distinct types of adipose tissue, white and brown (WAT and BAT), requires an even more complex regulation of adipose tissue development. In this review we will focus on the role of PPARγ coregulators in adipogenesis and especially on the role of PPARγ coregulators in white and brown adipose tissue. Specificity in coregulator function in WAT and BAT may form an additional level of regulation of adipose tissue development.

Keywords: Adipogenesis, Transcription, Coactivator, Corepressor, White and brown adipose tissue, PPARgamma

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0014-5793(10)00530-2

doi:10.1016/j.febslet.2010.06.035

FEBS Letters
Volume 584, Issue 15 , Pages 3250-3259, 4 August 2010

Article Tools

* Image Usage & Resolution