FEBS Letters
Volume 584, Issue 17 , Pages 3682-3695, 10 September 2010

The MRN complex in double-strand break repair and telomere maintenance

Edited by Wilhelm Just

  • Brandon J. Lamarche

      Affiliations

    • Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    • ,
  • Nicole I. Orazio

      Affiliations

    • Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    • Graduate Program, Division of Biology, University of California, San Diego, CA 92093, USA
    • ,
  • Matthew D. Weitzman

      Affiliations

    • Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    • Corresponding Author InformationCorresponding author. Fax: +1 858 558 7454.

Received 16 June 2010; received in revised form 16 July 2010; accepted 19 July 2010. published online 22 July 2010.

Abstract 

Genomes are subject to constant threat by damaging agents that generate DNA double-strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA damage recognition and end-joining, and this is achieved through protein–DNA complexes known as telomeres. The Mre11–Rad50–Nbs1 (MRN) complex plays important roles in detection and signaling of DSBs, as well as the repair pathways of homologous recombination (HR) and non-homologous end-joining (NHEJ). In addition, MRN associates with telomeres and contributes to their maintenance. Here, we provide an overview of MRN functions at DSBs, and examine its roles in telomere maintenance and dysfunction.

Keywords: MRN complex, DNA damage, DNA repair, DSB, Telomere

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PII: S0014-5793(10)00587-9

doi:10.1016/j.febslet.2010.07.029

FEBS Letters
Volume 584, Issue 17 , Pages 3682-3695, 10 September 2010

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