FEBS Letters
Volume 584, Issue 17 , Pages 3812-3818, 10 September 2010

TERRA biogenesis, turnover and implications for function

Edited by Wilhelm Just

  • Sascha Feuerhahn

      Affiliations

    • These authors contributed equally and are listed alphabetically.
    • ,
  • Nahid Iglesias

      Affiliations

    • These authors contributed equally and are listed alphabetically.
    • ,
  • Andrea Panza

      Affiliations

    • These authors contributed equally and are listed alphabetically.
    • ,
  • Antonio Porro

      Affiliations

    • These authors contributed equally and are listed alphabetically.
    • ,
  • Joachim Lingner

      Affiliations

    • Corresponding Author InformationCorresponding author. Fax: +41 21 693 0720.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 19, 1015 Lausanne, Switzerland

Received 1 July 2010; received in revised form 19 July 2010; accepted 20 July 2010. published online 23 July 2010.

Abstract 

Telomeres are heterochromatic structures at the ends of eukaryotic chromosomes. As other heterochromatin regions, telomeres are transcribed, from the subtelomeric region towards chromosome ends into the long non-coding RNA TERRA. Telomere transcription is a widespread phenomenon as it has been observed in species belonging to several kingdoms of the eukaryotic domain. TERRA is part of telomeric heterochromatin in addition to being present in the nucleoplasm. Here, we review the current knowledge of TERRA structure, biogenesis and turnover. In addition, we discuss presumed roles of this RNA during replication of telomeric DNA, heterochromatin formation and the regulation of telomerase.

Keywords: TERRA, Non-coding RNA, Telomere, Telomerase

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PII: S0014-5793(10)00590-9

doi:10.1016/j.febslet.2010.07.032

FEBS Letters
Volume 584, Issue 17 , Pages 3812-3818, 10 September 2010

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