FEBS Letters
Volume 584, Issue 17 , Pages 3826-3830, 10 September 2010

The role of telomeres and telomerase in stem cell aging

Edited by Wilhelm Just

  • Ignacio Flores

      Affiliations

    • Stem Cell Group, Cardiovascular Development Biology Program, Spanish National Cardiovascular Research Centre (CNIC), Melchor Fernández Almagro 3, Madrid, E-28029, Spain
    • ,
  • Maria A. Blasco

      Affiliations

    • Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernández Almagro Street, Madrid E-28029, Spain
    • Corresponding Author InformationCorresponding author. Address: Spanish National Cancer Research Centre (CNIO), 3 Melchor Fernandez Almagro street, Madrid E-28029, Spain. Fax: +34 91 732 8028.

Received 9 July 2010; received in revised form 23 July 2010; accepted 23 July 2010. published online 30 July 2010.

Abstract 

Stem cells regenerate our bodies. In a similar manner to match ignition, stem cell “ignition” has to be precisely tuned to avoid uncontrolled proliferation as may occur in tumors or, inversely, the lack of proliferation as happens in degenerative disorders. During the last years it has become evident that telomeres and telomerase are main components of the stem cell “ignition” mechanism, providing a way to restrain cancer and delay aging.

Keywords: Telomere, Telomerase, Stem cell, Pluripotency, p53

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PII: S0014-5793(10)00604-6

doi:10.1016/j.febslet.2010.07.042

FEBS Letters
Volume 584, Issue 17 , Pages 3826-3830, 10 September 2010

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