FEBS Letters Molecular Medicine Virtual Special Issue

FEBS Letters is proud to launch a new series of Virtual Special Issues which will highlight a collection of outstanding articles recently published in the journal, focusing on a selection of topics that we hope will be of general interest to our readers. The first of the series is a Virtual Special Issue on Molecular Medicine. The topic is deliberately broad, as we believe that this diversity is the strength of our journal, and will be appreciated by scientists from all fields.

Molecular Medicine is a discipline in which modern biochemical research approaches are applied to understand the molecular mechanisms at the base of disease. Every scientific publication in the field of Molecular Medicine is a tiny, but indispensable, piece of the puzzle that must be completed in order to cure diseases. Here, we are presenting articles on pathologies ranging from Alzheimer's disease to cystic fibrosis, and have grouped them according to the major organs of the human body that they affect. In this issue you can find out how Wnt signalling can promote hepatic fibrosis by enhancing hepatic stellate cell activation and survival, or how an optineurin mutant can cause a familial form of glaucoma by over-interacting with TBK1. Are you aware that urine is a possible source of prion transmission? Do you know how activated macrophages can induce proteinuria in glomerular diseases? Find these and many other interesting articles in the FEBS Letters Molecular Medicine Virtual Special Issue. We wish you a pleasant and fruitful read!


Molecular Medicine cover

Table of Contents

I. Alzheimer's and brain related diseases
II. Heart related diseases
III. Kidney related diseases
IV. Diabetes and Metabolism
V. Liver related diseases
VI. Pathologies of the eye
VII. Diseases of the connective tissue
VIII. Cystic Fibrosis
IX. Metabolic Detection


I. Alzheimer's and brain related diseases

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The role of glycogen synthase kinase 3 in the early stages of Alzheimers’ disease

26 November 2008 (Vol. 582 | No. 28 | Pages 3848-3854)

Félix Hernández, Jesús Avila Short survey

3848-3854
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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

23 January 2008 (Vol. 582 | No. 2 | Pages 359-364)

Ying Liu, Fei Liu, Khalid Iqbal, Inge Grundke-Iqbal, Cheng-Xin Gong et al. Short communication

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359-364
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The correlation between neurotoxicity, aggregative ability and secondary structure studied by sequence truncated Aβ peptides

20 March 2007 (Vol. 581 | No. 6 | Pages 1161-1165)

M.Q. Liao, Y.J. Tzeng, Lea Y.X. Chang, H.B. Huang, T.H. Lin, C.L. Chyan, Y.C. Chen et al. Short communication

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1161-1165
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Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury

6 February 2007 (Vol. 581 | No. 3 | Pages 495-505)

Quan-Guang Zhang, Dong-Na Wu, Dong Han, Guang-Yi Zhang Short communication

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495-505
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RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosis

12 November 2008 (Vol. 582 | No. 27 | Pages 3823-3831)

Arjun Saha, Sung-Jo Kim, Zhongjian Zhang, Yi-Ching Lee, Chinmoy Sarkar, Pei-Chih Tsai, Anil B. Mukherjee et al. Short communication

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3823-3831
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II. Heart related diseases

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CD36 is a receptor for oxidized high density lipoprotein: Implications for the development of atherosclerosis

20 March 2007 (Vol. 581 | No. 6 | Pages 1227-1232)

Rick F. Thorne, Nizar M. Mhaidat, Kylie J. Ralston, Gordon F. Burns Short communication

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1227-1232
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Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation

6 February 2007 (Vol. 581 | No. 3 | Pages 526-534)

Chun-Hsu Pan, Jiunn-Lee Lin, Ling-Ping Lai, Chien-Lung Chen, Shoei K. Stephen Huang, Chih-Sheng Lin et al. Short communication

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526-534
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Activation of peroxisome proliferator-activated receptor-α prevents glycogen synthase 3β phosphorylation and inhibits cardiac hypertrophy

10 July 2007 (Vol. 581 | No. 17 | Pages 3311-3316)

Ruifang Li, Wenhua Zheng, Rongbiao Pi, Jie Gao, Huijie Zhang, Ping Wang, Kang Le, Peiqing Liu et al. Short communication

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3311-3316
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Endogenous microRNAs induced by heat-shock reduce myocardial infarction following ischemia–reperfusion in mice

24 December 2008 (Vol. 582 | No. 30 | Pages 4137-4142)

Chang Yin, Xiaoyin Wang, Rakesh C. Kukreja Short communication

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4137-4142
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Involvement of Sema4A in the progression of experimental autoimmune myocarditis

26 November 2008 (Vol. 582 | No. 28 | Pages 3935-3940)

Nobuhiko Makino, Toshihiko Toyofuku, Noriko Takegahara, Hyota Takamatsu, Tatsusada Okuno, Yukinobu Nakagawa, Sujin Kang, Satoshi Nojima, Masatsugu Hori, Hitoshi Kikutani, Atsushi Kumanogoh et al. Short communication

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3935-3940
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III. Kidney related diseases

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Transcriptional suppression of nephrin in podocytes by macrophages: Roles of inflammatory cytokines and involvement of the PI3K/Akt pathway

6 February 2007 (Vol. 581 | No. 3 | Pages 421-426)

Yosuke Takano, Kozue Yamauchi, Kunihiro Hayakawa, Nobuhiko Hiramatsu, Ayumi Kasai, Maro Okamura, Makiko Yokouchi, Akihiro Shitamura, Jian Yao, Masanori Kitamura et al. Short communication

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421-426
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Uteroglobin interacts with the heparin-binding site of fibronectin and prevents fibronectin–IgA complex formation found in IgA-nephropathy

5 March 2008 (Vol. 582 | No. 5 | Pages 611-615)

Bhabadeb Chowdhury, Zhongjian Zhang, Anil B. Mukherjee Short communication

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611-615
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IV. Diabetes and Metabolism

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Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53

6 March 2007 (Vol. 581 | No. 5 | Pages 1071-1078)

Kulbhushan Tikoo, Durga Nand Tripathi, Dhiraj G. Kabra, Vikram Sharma, Anil Bhanudas Gaikwad et al. Short communication

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1071-1078
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l-Arginine prevents metabolic effects of high glucose in diabetic mice

23 July 2008 (Vol. 582 | No. 17 | Pages 2609-2614)

Matthew B. West, Kota V. Ramana, Karin Kaiserova, Satish K. Srivastava, Aruni Bhatnagar et al. Short communication

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2609-2614
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Negative regulation of adiponectin receptor 1 promoter by insulin via a repressive nuclear inhibitory protein element

15 October 2008 (Vol. 582 | No. 23 | Pages 3401-3407)

Xiaolan Sun, Jing He, Chenqian Mao, Ruijun Han, Zhenzhen Wang, Yong Liu, Yan Chen et al. Short communication

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3401-3407
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V. Liver related diseases

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PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA

26 June 2007 (Vol. 581 | No. 16 | Pages 3098-3104)

Hongtao Wang, Yan Zhang, Robert O. Heuckeroth Short communication

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3098-3104
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Wnt signaling enhances the activation and survival of human hepatic stellate cells

26 June 2007 (Vol. 581 | No. 16 | Pages 2954-2958)

Sun Jung Myung, Jung-Hwan Yoon, Geum-Youn Gwak, Won Kim, Jeong-Hoon Lee, Kang Mo Kim, Chan Soo Shin, Ja June Jang, Sung-Hee Lee, Soo-Mi Lee, Hyo-Suk Lee et al. Short communication

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2954-2958
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Hepatic stellate cell damage may lead to decreased plasma ADAMTS13 activity in rats

17 April 2007 (Vol. 581 | No. 8 | Pages 1631-1634)

Yukio Kume, Hitoshi Ikeda, Morihiro Inoue, Kazuaki Tejima, Tomoaki Tomiya, Takako Nishikawa, Naoko Watanabe, Tatsuya Ichikawa, Makoto Kaneko, Shigeo Okubo, Hiromitsu Yokota, Masao Omata, Kenji Fujiwara, Yutaka Yatomi et al. Short communication

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1631-1634
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VI. Pathologies of the eye

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A Stargardt disease-3 mutation in the mouse Elovl4 gene causes retinal deficiency of C32–C36 acyl phosphatidylcholines

27 November 2007 (Vol. 581 | No. 28 | Pages 5459-5463)

Anne McMahon, Shelley N. Jackson, Amina S. Woods, Wojciech Kedzierski Short communication

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5459-5463
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Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma

19 March 2008 (Vol. 582 | No. 6 | Pages 997-1002)

Simon Morton, Luke Hesson, Mark Peggie, Philip Cohen Short communication

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997-1002
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VII. Diseases of the connective tissue

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Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation

16 April 2008 (Vol. 582 | No. 9 | Pages 1313-1318)

Rieko Ajima, Toru Akiyama, Michihiko Usui, Mitsuhiro Yoneda, Yutaka Yoshida, Takahisa Nakamura, Osamu Minowa, Masaki Noda, Sakae Tanaka, Tetsuo Noda, Tadashi Yamamoto et al. Short communication

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1313-1318
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Pathogenic mitochondrial DNA-induced respiration defects in hematopoietic cells result in anemia by suppressing erythroid differentiation

1 May 2007 (Vol. 581 | No. 9 | Pages 1910-1916)

Shin-Ichi Inoue, Mutsumi Yokota, Kazuto Nakada, Hiroyuki Miyoshi, Jun-Ichi Hayashi et al. Short communication

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1910-1916
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VIII. Cystic Fibrosis

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The lactoperoxidase system links anion transport to host defense in cystic fibrosis

23 January 2007 (Vol. 581 | No. 2 | Pages 271-278)

Gregory E. Conner, Corinne Wijkstrom-Frei, Scott H. Randell, Vania E. Fernandez, Matthias Salathe et al. Short communication

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271-278
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IX. Metabolic Detection

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Circulating (cell-free) nucleic acids – A promising, non-invasive tool for early detection of several human diseases

6 March 2007 (Vol. 581 | No. 5 | Pages 795-799)

Vishnu Swarup, M.R. Rajeswari Short survey

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795-799
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Detection of infectious prions in urine

22 September 2008 (Vol. 582 | No. 21 | Pages 3161-3166)

Dennisse Gonzalez-Romero, Marcelo A. Barria, Patricia Leon, Rodrigo Morales, Claudio Soto et al. Short communication

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3161-3166
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