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Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies
03 February 2012
Ritankar Majumdar, Reema Railkar, Rajan R Dighe
Highlights: ► First report of novel agonistic and antagonistic scFvs against LHR Hinge region. ► Discontinuous epitope of agonistic scFv comprises regions in both Cb-2 and Cb-3. ► Development of inver...
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Construction of synthetic regulatory networks in yeast
03 February 2012
Benjamin A. Blount, Tim Weenink, Tom Ellis
Abstract: Yeast species such as Saccharomyces cerevisiae have been exploited by humans for millennia and so it is therefore unsurprising that they are attractive cells to re-engineer for industrial us...
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Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
03 February 2012
Na Li, Bin Tang, En-Dong Zhu, Bo-sheng Li, Yuan Zhuang, Shu Yu, Dong-shui Lu, Quan-Ming Zou, Bin Xiao, Xu-Hu Mao
Highlights: ► miR-222 is up-regulated both by H. pylori infection and in gastric cancer.. ► Over-expression of miR-222 promotes cell proliferation and colony formation.. ► RECK is a novel target of mi...
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ATX and LPA receptor 3 are coordinately up-regulated in lipopolysaccharide-stimulated THP-1 cells through PKR and SPK1-mediated pathways
03 February 2012
Song Li, Chaoyang Xiong, Junjie Zhang
Highlights: ► ATX and LPA3 are coordinately up-regulated by LPS in human monocytic THP-1 cells. ► PKR-mediated JNK1 and p38 MAPK activation is required for ATX and LPA3 induction. ► SPK1-mediated PI3K...
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Pro42 and Val45 of Staphylokinase modulate intermolecular interactions of His43-Tyr44 pair and specificity of Staphylokinase-plasmin activator complex
03 February 2012
Satish Singh, Fnu Ashish, Kanak L. Dikshit
Highlights: ► Mutations at Pro42 and Val45 of SAK abrogate its Pg activation property. ► Pro42 and Val45 modulate contacts of His43-Tyr44 pair of SAK with Trp215 of plasmim. ► His43 is vulnerable than...
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